Gender Dysphoria and Autism Spectrum Disorder: A Systematic Review of the Literature

Author links open overlay panelDerekGliddenMD1Walter PierreBoumanMD, FRCPsych1Bethany A.JonesMSc12JonArcelusMD, PhD13

Abstract

Introduction

There is a growing clinical recognition that a significant proportion of patients with gender dysphoria have concurrent autism spectrum disorder (ASD).

Aim

The purpose of this review is to systematically appraise the current literature regarding the co-occurrence of gender dysphoria and ASD.

Methods

A systematic literature search using Medline and PubMed, PsycINFO, and Embase was conducted from 1966 to July 2015.

Main Outcome Measures

Fifty-eight articles were generated from the search. Nineteen of these publications met the inclusion criteria.

Results

The literature investigating ASD in children and adolescents with gender dysphoria showed a higher prevalence rate of ASD compared with the general population. There is a limited amount of research in adults. Only one study showed that adults attending services for gender dysphoria had increased ASD scores. Another study showed a larger proportion of adults with atypical gender identity and ASD.

Conclusion

Although the research is limited, especially for adults, there is an increasing amount of evidence that suggests a co-occurrence between gender dysphoria and ASD. Further research is vital for educational and clinical purposes.

來源：https://www.sciencedirect.com/science/article/pii/S2050052115000049